Mac storage basics · Caches, logs and temporary files
How do I free space used by DaVinci Resolve's cache?
Short answer: Use Playback → Delete Render Cache, remove unneeded optimised media, and set the cache location (Working Folders in Project Settings) to a fast external drive.
Resolve keeps render cache and optimised media in its CacheClip location. Use Playback → Delete Render Cache (all or unused), and remove optimised media from the Media Pool when it isn't needed. You can set where cache files go in Project Settings → Master Settings → Working Folders, for example to a fast external drive.
Everything here is regenerated when needed.