Mac storage basics · Caches, logs and temporary files
How do I clear Google Chrome's cache on a Mac?
Short answer: In Chrome go to Settings → Privacy and security → Delete browsing data, choose Cached images and files, and leave cookies unticked to stay signed in.
In Chrome, open Settings → Privacy and security → Delete browsing data (or press Shift-Command-Delete), pick a time range, tick Cached images and files only, and confirm. Leaving cookies unticked keeps you signed in.
Chrome's profile folder can still be large because of extensions, service workers and offline site data. Don't move or delete the whole profile folder by hand — it also holds your passwords, cookies and history.
Storage Studio deliberately never offers to move a browser's profile folder for the same reason. See freeing up space.